J&J Family of Companies Post-Doc Immune metabolism in Beerse, Belgium

The Pharmacokinetics, Dynamics and Metabolism department of Discovery Sciences serves the various Therapeutic Area’s with ‘state-of-the-art’ analytical support in e.g. PK/PD studies, biomarker evaluation, ‘mode-of-action’ research, target binding/confirmation essay’s and conjugate analysis to support the discovery and development of (mainly) novel small molecule therapies. The department integrates metabolomics technologies in the existing High Throughput and (semi-)quantitative workflows to accelerate drug discovery and development. To support the on-going efforts to further elucidate & understand molecular mechanisms in disease, we like to strengthen our team with a

Post-Doc (2 yr’s) immune pharmacology (m/f)

  • Develop/optimize novel UPLC-MS/MS and UPLC-HR-MS methods for the analysis of selected endogenous metabolites from cellular systems, biofluids and tissue

  • Design, in collaboration with our in-vitro and in-vivo experts, Immunological relevant tracer studies focused on e.g. T-cell or macrophage differentiation

  • Design metabolic quenching protocols for instantaneous arresting active metabolism in in-vitro and in-vivo samples

Qualifications

  • PhD in (Analytical) Chemistry, Pharmacology or a related discipline with a strong analytical component

  • Extensive hands-on experience with modern LC-MS/MS and/or LC-High Resolution MS instrumentation and sample preparation techniques for analysis of biofluids, tissues and cellular systems

  • Practical analytical method developer and demonstrated troubleshooter

  • Practical experience with quantitative metabolomics and data evaluation packages

  • Proven data analysis and interpretation skills of complex data sets

  • Hands-on experience with cellular systems, cell sorting technologies in the field of immunology and/or inflammation

Competencies

  • Able to manage multiple projects in parallel with challenging timelines

  • Good communicator and team-player, both orally and in writing

  • Good interpersonal skills

  • Results driven nature

  • Hands-on attitude

Primary Location

Belgium-Antwerp-Beerse

Organization

Janssen Pharmaceutica N.V. (7555)

Job Function

Pharmacokinetics

Requisition ID

1805642846W